Chronic Lyme disease often presents with debilitating symptoms like fatigue and brain fog, affecting many who either remain untreated or are misdiagnosed. Co-infections, such as Babesia and Bartonella, complicate the picture, with a significant number of patients experiencing multiple infections. The interplay of genetics and epigenetics plays a crucial role in how individuals respond to Lyme, highlighting the need for more comprehensive approaches in both conventional and functional medicine.