EP 319: An Exploration of HPV-Correlated C@ncers with Dr. Mohammad Kamal

Tumor Analysis

Modern pathology has revolutionized tumor analysis, offering insights into diagnosis and treatment. Mohammad Kamal explains that traditional methods focused on microscopic evaluation to distinguish between benign and malignant tumors. However, advancements now allow for antigen-antibody reactions and genetic testing, providing a deeper understanding of tumor characteristics and treatment responses 1. This progression in pathology is crucial for personalized medicine, as it enables tailored treatment plans based on individual tumor profiles.

Traditionally, pathology was looking at the microscopic evaluation, and we say, this is benign or malignant.

--- Mohammad Kamal

Anthony DiClementi highlights the importance of these developments in understanding the complexities of cancer and its treatment 2.

   

Testing Developments

Dr. Kamal's contributions to pathology include pioneering testing protocols for HPV-related cancers. He notes the rise of HPV-related throat cancer, which now surpasses cervical cancer cases in men due to the lack of screening guidelines 3. By adapting FDA-approved cervical HPV tests for oropharyngeal samples, his lab developed a highly accurate assay, addressing a critical gap in cancer screening.

We took the FDA approved cervical hpv test, and we validated it on oropharyngeal samples, and we ended up with a wonderful assay.

--- Mohammad Kamal

Kamal envisions his legacy as one that contributes to societal betterment through knowledge sharing and innovation in medical testing 4.