Rapid Antidepressant Effects

Ketamine and psilocybin demonstrate rapid antidepressant effects, often improving severe depression and suicidality within 24 hours. While both substances promote neuroplastic changes in the brain, psilocybin offers longer-lasting benefits, sometimes extending for months after just a couple of doses. The differences in duration of effects between the two drugs remain an intriguing mystery in the field of mental health treatment.