Published Aug 28, 2024

Is L-Arginine the key to Stronger and Longer Lasting Erections?

Dr. Rena Malik delves into the science behind L-Arginine and L-Citrulline, exploring their benefits, bioavailability, and efficacy in improving erectile function and managing mild erectile dysfunction.
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  • Mechanism

    L-Citrulline offers a promising alternative to L-Arginine due to its superior bioavailability. explains that L-Citrulline is converted into L-Arginine in the kidneys, leading to a more sustained release and avoiding breakdown by intestinal and liver enzymes 1. This conversion process enhances blood levels of L-Arginine more effectively than oral L-Arginine itself. Additionally, L-Citrulline may encourage penile muscles to release vascular endothelial growth factor (VEGF), improving blood vessel function in the penis 1.

    Oral citrulline is better than oral arginine at increasing blood levels of arginine itself.

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    Though data on L-Citrulline is less robust, early studies suggest its potential in restoring healthy blood vessel function in the penis.

       

    Effectiveness

    Studies have shown that L-Citrulline can improve erectile hardness in men with mild erectile dysfunction. discusses a study where participants took 1.5 grams of L-Citrulline daily, resulting in improved erectile hardness scores for about half of the men 2. The study used a placebo control, and the results indicated a significant improvement in the L-Citrulline group compared to the placebo group.

    They found that in the men who took L-Citrulline, they saw an improvement, about half of them in their erectile hardness score from three to four.

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    L-Citrulline is also noted for its relative safety and minimal side effects, making it a viable option for those seeking to enhance erectile function.