Urologist Explains Retrograde Ejaculation, Vaginal Dryness and Tadalafil | AMA
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Episode Highlights
Benefits
Dr. discusses the differences between tadalafil and sildenafil, two common medications for erectile dysfunction. She notes that tadalafil has a longer half-life, lasting up to 36 hours, which allows for more spontaneity. Additionally, tadalafil can be taken with food, unlike sildenafil, which must be taken on an empty stomach 1. This makes tadalafil a more convenient option for many users.
You don't have to take it on an empty stomach. So sildenafil, you have to take on an empty stomach, which means that you can't have a big dinner before you can't, you know, eat a big meal.
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Dr. Malik also mentions that tadalafil can be taken daily, reducing the stress of timing the medication with sexual activity 2.
Mechanism
The mechanism of action for tadalafil involves inhibiting phosphodiesterase five, which helps sustain erections by maintaining higher levels of nitric oxide. explains that nitric oxide is crucial for initiating erections as it is released in response to sexual stimulation 1. This process allows for improved blood flow and prolonged erections.
Your body makes nitric oxide from the blood vessels and the nerves in response to any sort of stimulation.
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She also highlights that while all erectile dysfunction medications are about 60% to 70% effective, individual responses can vary, and some may work better for certain people 1.