Joe Rogan Experience #994 - Dom D'Agostino

Cognitive Boost

Exogenous ketones are gaining attention for their potential to enhance cognitive function. Dom D'Agostino explains how caprylic triglyceride, a medium-chain triglyceride found in certain supplements, can elevate ketone levels in the blood, leading to improved cognitive performance, especially in individuals with mild cognitive impairment 1. This correlation between ketone levels and cognitive enhancement is significant, as even a small increase in ketones can boost brain energy by about 10% 1. Joe Rogan highlights the potential for exogenous ketones to be a standard supplement for those needing mental acuity, such as students or professionals facing demanding tasks 2.

   

Performance Edge

Exogenous ketones are not only beneficial for cognitive enhancement but also for improving physical performance. Dom D'Agostino shares his personal experience of using ketones to maintain performance during periods of extreme sleep deprivation, such as when traveling and lecturing with no rest 2. He emphasizes the importance of combining beta-hydroxybutyrate with medium-chain triglycerides to maximize the benefits, as this combination sustains elevated ketone levels longer 2. Joe Rogan suggests that ketones could help mitigate adrenaline rushes and focus issues during high-stress activities like hunting 3.

   

Biochemical Benefits

The biochemical interactions of exogenous ketones with the body reveal fascinating insights. Dom D'Agostino notes that ketones can lower blood glucose levels, potentially by enhancing insulin sensitivity or affecting liver glucose regulation 4. This makes ketones a unique energy source, especially for the brain, as they bypass certain metabolic pathways that glucose cannot, offering a more efficient energy supply 4. Joe Rogan5.