157. The More Plates More Dates podcast with Derek!

Insulin Resistance

Insulin resistance is a multifaceted issue that Paul Saladino and Derek dissect in detail. Paul emphasizes the importance of a nutrient-rich, toxin-free diet and lifestyle changes over medications for managing diabetes. He believes that diabetes is fixable without medications if people adopt healthier habits, such as eating more nutrient-rich foods and avoiding junk food 1. Derek adds that insulin plays a crucial role in anabolic processes, which can be both beneficial and potentially harmful, depending on the context 2.

We're going to fix diabetes, this is fixable and we're giving people meds, and not necessarily within mainstream western medicine saying, hey, this is a fixable disease.

--- Paul Saladino

Paul also discusses the role of broken fat cells in metabolic dysfunction and how insulin resistance often starts in the fat cells 2.

   

Role of LDL

The role of LDL in heart disease and metabolic health is another critical topic. Paul argues that LDL is essential for human life and questions the traditional view that it is inherently harmful. He suggests that metabolic health, rather than LDL levels alone, is a more accurate indicator of heart disease risk 3. Derek and Paul discuss the concept of lean mass hyper-responders, who have high LDL but are metabolically healthy, challenging the mainstream LDL paradigm 4.

The LDL molecule, it's a lipoprotein, it's essential for human life. So it doesn't make sense to me at a high level, intuitively, why it would also be killing us.

--- Paul Saladino

They highlight the need for a paradigm shift in how LDL and metabolic health are understood and managed in medicine.

   

Food Choices

Food choices and their impact on satiety and metabolic health are also discussed. Paul believes that calorie-restricted diets are unsustainable and advocates for eating to satiety with high-quality foods to achieve a good body composition. He shares his own dietary habits, which include a high intake of protein, carbohydrates, and fats 5. Derek and Paul also discuss the negative impact of seed oils on satiety and metabolic health, even in a caloric deficit 6.

Where they can eat basically to satiety of a select group of high quality foods and still achieve a good body composition. That's living to me. That's a higher quality of life.

--- Paul Saladino

They emphasize the importance of nutrient adequacy and the potential long-term disadvantages of consuming processed foods and seed oils.