Dr. Peter Attia - longevity compounds, fasting, supplements and more
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Longevity
and explore the potential of Rapamycin as a longevity compound. Kevin highlights a 2014 study showing Rapamycin extended the lifespan of mice by over 20%, dubbing it a "caloric restriction in a pill" 1. Peter explains the complexity of dosing Rapamycin for humans, emphasizing the need to inhibit mTOR complex one without affecting complex two 2. He notes that while Rapamycin is available by prescription, its use for longevity is still under investigation.
It's hard to develop a drug that treats something that is not a disease.
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The conversation underscores the challenges in translating animal research to human applications, especially for non-disease indications like aging.
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Side Effects
Rapamycin's side effects are a significant consideration in its use. describes the common occurrence of mouth sores, or apathos ulcers, as a notable side effect, which he personally experienced for two months 3. He emphasizes the importance of dosing to avoid inhibiting mTOR complex two, which can lead to adverse effects 4.
The first two months, I had really bad apathy ulcers.
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Despite these challenges, Peter notes that some patients experience metabolic benefits, such as improved glucose levels and reduced triglycerides, particularly those with poorer initial metabolic health.
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Animal Studies
Animal studies provide intriguing insights into Rapamycin's effects. discusses how Rapamycin has been shown to improve cardiac function in dogs, potentially due to enhanced autophagy and mitophagy in heart cells 5. He also explains the role of mitochondrial DNA in inflammation, suggesting that Rapamycin might mitigate age-related inflammation by promoting mitochondrial recycling 6.
The effect has been profound... a 10% improvement in ejection fraction.
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These findings highlight the potential of Rapamycin to address age-related health issues, though translating these results to humans remains complex.