202 - Peter on nutrition, disease prevention, and more — looking back on the last 100 episodes

Apob Reduction

Peter Attia underscores the importance of early and aggressive Apob reduction to prevent atherosclerotic cardiovascular disease (ASCVD). He explains that Apob levels should ideally be kept below 60 milligrams per deciliter, as lower levels significantly reduce the risk of ASCVD. Peter shares his personal approach to managing Apob levels and highlights the various therapeutic options available, including statins and PCSK9 inhibitors 1 2.

The evidence is overwhelming that infantile levels of Apob are not deleterious in any way.

--- Peter Attia

Additionally, he stresses the importance of measuring Apob levels during routine check-ups to ensure early detection and intervention 2.

   

Genetics and Alzheimer's

Understanding the genetic factors beyond APOE is crucial in modifying Alzheimer's disease risk. Peter Attia discusses the significance of genes like Tom 40 and Clotho, which can amplify or mitigate the risk associated with the APOE4 variant. He notes that while genetic testing is currently labor-intensive and costly, advancements could make it more accessible in the future 3.

There are certain haplotypes of the Tom 40 gene that amplify risk.

--- Peter Attia

Peter also mentions ongoing efforts to streamline genetic testing processes, which could lead to more personalized and effective prevention strategies 4.