Understanding MTHFR and Methylation
Explore the spectrum of MTHFR function and the impact on methylation. Discover the correlation between MTHFR status and homocysteine levels, as well as the role of riboflavin in optimizing MTHFR activity. Challenge the simplistic view of B6 as the solution and delve into a more nuanced approach to clinical treatment.In this clip
From this podcast

The Peter Attia Drive Podcast
#46–Chris Masterjohn, Ph.D.: Pathways to health and disease (NAD, sirtuins, methylation, choline...
Related Questions
Given that all my levels are within the green range—even homocysteine—does my MTHFR mutation still warrant supplementation with L-5-MTHF, methylcobalamin, or other methylation-support nutrients?
How is it physiologically possible that I have a TT mutation (which only allows \~30% methylation efficiency) yet my homocysteine and folate are both normal? Could I still be deficient at the cellular level or in cerebrospinal fluid?
What is methylation in relation to the MTHFR C677T mutation?