Estrogen is typically administered transdermally to reduce risks associated with oral intake, particularly for issues like hot flashes and bone density. Vaginal estrogen presents a safe option for women with a history of breast cancer, offering relief from vaginal dryness with minimal systemic absorption. Progesterone can be calming and is often used orally for sleep and anxiety, while synthetic versions like Provera may lead to undesirable side effects, making natural alternatives preferable.
