Exercise triggers the release of endocannabinoids, which are crucial for experiencing the runner's high. While endorphins play a role, they can't cross the blood-brain barrier, leading to confusion about their impact. The real magic happens when endocannabinoids and brain-produced endorphins combine, lighting up the brain's reward system and making it easier to keep moving. This highlights how our bodies can produce their own "pharmaceuticals" through physical activity.
