Unlocking Youthful Gene Expression
David Sinclair explains how mislocalized sirtuins can lead to a decline in youthful gene expression and health as we age. He reveals the crucial role of NAD in activating sirtuins and discusses its impact on repairing DNA and silencing genes. Discover the key to keeping sirtuins active and maintaining optimal cellular function.In this clip
From this podcast

Rich Roll
David Sinclair Is Extending Human Lifespan | Rich Roll Podcast
Related Questions
How does NAD relate to sirtuins?
How does NAD+ activate sirtuins in the episode Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52 and the clip Sirtuins and Aging?
How does NAD relate to sirtuins in the context of the episode 170: Why aging may be a disease we can reverse, with microbiologist David Sinclair, Ph.D. and the clip Understanding NAD and Sirtuins?