Published February 2016 on Spotfiy

Dr. Rhonda Patrick, on cold stress and longevity hacking

1. Exploring Longevity

Dive into the world of longevity with a scientist who shares insights on body hacking, nutrition, and cancer prevention. Discover the secrets to living a longer and healthier life.+

2. Body Hacking

Discover the amazing benefits of body hacking through sauna and cold weather exposure. Join Kevin as he interviews Dr. Rhonda Patrick, a renowned scientist and researcher, who shares insights on the positive effects of these practices on the body. Learn how simple steps like cold showers can lead to improved mood and better sleep. Get ready to dive deep into the science behind body hacking.+

3. Science & Health Journey

Dr. Rhonda Patrick shares her fascinating journey from chemistry to biology, and how her research in aging and cancer led her to a passion for metabolism and nutrition. Discover the insights she gained and the preventative approach she takes with aging.+

4. Optimizing Health

Dr. Rhonda Patrick and Kevin Rose discuss the ways to optimize our biology for a healthier and more youthful life. They delve into various topics such as diet, lifestyle choices, and the benefits of cold therapy. Kevin shares his personal experience with cold training and its positive effects on his mood and recovery. Tune in to discover the fascinating insights from Dr. Rhonda Patrick's research and reports.+

5. Cold Shock Therapy: Its Hormesis

Unleashing the Power of Hormesis:Dr. Rhonda Patrick explains the concept of hormesis, the practice of exposing the body to small doses of stress that can have beneficial effects. She discusses how exercise and cold shock therapy can activate hardwired genetic pathways and improve overall health and aging.+
Cold Exposure Benefits:Dr. Rhonda Patrick explains how cold exposure triggers the release of norepinephrine, a neurotransmitter that improves mood. The duration of exposure affects the level of norepinephrine released, but even brief exposure has long-term effects on mood.+
Cold Showers and Hot Baths:Dr. Rhonda Patrick discusses the long term effects of cold showers and hot baths on long term potentiation and mood improvement. She explores the possibility of reversing these effects and the potential synergistic effect of combining hot and cold exposures. Kevin Rose shares his personal experience with cold plunges and the profound euphoric effects he feels.+

6. Going from hot to cold

Hot to Cold Benefits:Dr. Rhonda Patrick discusses the benefits of transitioning from hot to cold temperatures, including how it affects the body's vascular system and the release of Norepinephrine. She advises caution for individuals with preexisting heart conditions and recommends consulting a doctor before trying this method.+
Cold Exposure Benefits:Dr. Rhonda Patrick explains the body's response to cold exposure, including the transition from shivering to fat burning. She also discusses the impact of cold therapy on the brain, particularly the release of Norepinephrine, which has been linked to improved memory and focus, as well as anti-inflammatory effects.+
Unleashing Stress Response:Dr. Rhonda Patrick explains how short bursts of stress, like cold water immersion or cryotherapy, can activate the stress response pathway and increase Norepinephrine levels. These exposures have long-term benefits and do not lead to habituation. Just like exercise, exposing oneself to these stressful situations can strengthen the stress response mechanisms in the brain and body, enabling better coping with future stresses.+

7. Plant Compounds Unleash Health

Plant Compounds and Hormetic Stress:Dr. Rhonda Patrick discusses the fascinating world of plant compounds and their ability to elicit a hormetic stress response in our bodies. She highlights the beneficial effects of small doses of curcumin from turmeric and how it activates a genetic pathway that inhibits the transformation of procarcinogens into active carcinogens. Discover how hacking our system to activate stress-dealing genes can have a positive impact on our health.+
Natural Plant Pesticides:Dr. Rhonda Patrick discusses the fascinating world of natural plant pesticides and their potential health benefits. She explains how certain compounds found in cruciferous vegetables, such as kale and broccoli, can activate enzymes that prevent the formation of carcinogens and protect our DNA and cells from damage.+

8. Potent Anti-inflammatory Effects

Potent Anti-inflammatory Effects:Dr. Rhonda Patrick discusses the potent anti-inflammatory effects of isothiocyanates and curcumin in the brain and body. She explains how a liposomal complex called phytosome mariva can increase the bioavailability of curcumin, providing valuable insights on reducing inflammation.+
The Power of Turmeric:Dr. Rhonda Patrick discusses the incredible benefits of turmeric, specifically its ability to reduce inflammation and alleviate joint pain. She explains how curcumin, the active compound in turmeric, activates genes that combat inflammation in the body. Whether you have arthritis or not, turmeric can help reduce inflammation that we all experience on a daily basis.+

9. Inflammation and brain diseases

Understanding Inflammation:Dr. Rhonda Patrick explains the damaging effects of inflammation on our bodies and how it is linked to diseases like cancer and brain disorders. She breaks down the immune system's response and the role of telomeres in protecting our DNA.+
Inflammation & Aging:Dr. Rhonda Patrick explains how chronic inflammation can lead to accelerated aging and increased risk of cancer and neurodegenerative diseases. She highlights the role of gut health in managing inflammation and offers insights into the complex interaction between diet and genes.+

10. Understanding Gut Health

Dr. Rhonda Patrick explains how poor gut health can lead to chronic diseases such as arthritis, fibromyalgia, and depression. She also discusses the signs to look out for, such as chronic pain and abdominal discomfort, and emphasizes the importance of understanding the mechanisms and optimizing gut health.+

11. How to optimize for gut health

Gut Health Optimization:Learn how to optimize your gut health by feeding it the right foods and the importance of probiotics in maintaining a healthy gut barrier.+
The Gut-Brain Connection:Dr. Rhonda Patrick discusses the fascinating relationship between our gut and brain, highlighting the role of bacteria in producing neurotransmitters and the potential of probiotics in alleviating anxiety. She explains how certain types of fiber feed beneficial bacteria, leading to the production of chemical compounds that shape our immune system and brain function. This emerging field of research offers new insights into the importance of gut health for overall well-being.+

12. Unleashing GABA Potential

Unlocking GABA Potential:Discover the fascinating world of GABA-rich foods like brown rice and green tea, and how they may impact our health. Dr. Rhonda Patrick shares insights on the potential benefits of ingesting GABA and its connection to gut health and brain function.+
Powerful Probiotics:Dr. Rhonda Patrick discusses the benefits of BSL number three probiotics, which contain an impressive 450 billion bacteria. These probiotics have shown efficacy in treating various conditions such as irritable bowel syndrome, colitis, eczema, and even arthritis. Dr. Patrick explains how these probiotics can increase brain derived neurotrophic factor, promoting the growth of new neurons and supporting existing ones. She also shares insights on the best way to consume these probiotics for optimal results.+
Gut Health Insights:Dr. Rhonda Patrick discusses the challenges of taking probiotics and suggests that after a round of antibiotics, when there is more space available, might be the best time to introduce beneficial bacteria. She also speculates that fasting could potentially help eliminate harmful bacteria in the gut.+

13. The Power of Fasting

Dr. Rhonda Patrick discusses the fascinating benefits of fasting, including its ability to extend lifespan and improve health span. She explains how intermittent fasting can clear away damaged senescent cells and activate stress resistance genes. While more empirical evidence is needed, a 16-hour fast may have similar benefits.+

14. Intermittent Fasting Benefits

Discover the surprising benefits of intermittent fasting, including how it helped Hugh Jackman get shredded for Wolverine. Dr. Rhonda Patrick explains the mechanisms behind intermittent fasting and its positive effects on insulin sensitivity and stress management.Show transcript +

15. Unlocking Longevity

Unlocking Longevity:Dr. Rhonda Patrick explains the fascinating effects of intermittent fasting, particularly the activation of autophagy and its connection to resveratrol. Discover how these pathways can potentially extend lifespan and improve overall health.+
Plant Compounds, Hormesis, and Neurohormesis:Dr. Rhonda Patrick discusses the fascinating effects of plant compounds on the brain, specifically focusing on hormesis and neurohormesis. She explains how these compounds induce a slight stress response in the brain, leading to positive effects such as improved memory. Dr. Patrick also highlights the unique benefits of these compounds compared to pharmacological drugs.+
Metformin's Anti-Aging Effects:Dr. Rhonda Patrick discusses the potential anti-aging effects of metformin, a drug commonly used to treat type 2 diabetes. Preliminary data suggests that type 2 diabetics taking metformin may live 17% longer, sparking interest in its potential benefits for non-diabetic individuals as well.+


Unfortunately, a ten-minute segment was lost at the end of the podcast, but don't worry, you can still get all the valuable information from Dr.+