Excess sugar disrupts the HPA axis, leading to increased stress hormones like cortisol and adrenaline, which can negatively impact mood and mental health. The brain's reliance on glucose makes it vulnerable to inflammation and oxidative stress, potentially resulting in conditions such as depression and Alzheimer's. This vicious cycle of insulin resistance and stress not only affects neurotransmitter signaling but also harms gut health, further complicating overall well-being.