How do psychedelics work?

Andrew Huberman AI:

Psychedelics, in a nutshell, are thought to unleash sensory processing and make it less filtered. We constantly receive various inputs from our senses, and our brain has mechanisms to suppress some of these, allowing us to focus on specific things. Psychedelics can disrupt this process, leading to sensory blending where people might report being able to smell colors or hear trees.

Furthermore, compounds like psilocybin, which mimic serotonin, can selectively activate certain receptors in the brain, such as the serotonin 2A receptor. This activation can lead to enhanced ways of thinking and learning within a short session, often referred to as a "psilocybin journey". This process is linked to neuroplasticity, the ability of our brain to change and adapt.

However, it's important to note that while these effects can be profound, they can also be hazardous, particularly for individuals with preexisting psychological issues, young people, and those not under the supervision of a trained physician. Psychedelics are powerful tools, but they must be used with caution.