Depression is a complex condition that can significantly impact mood. It often leads to a state of low affect, where individuals may feel persistently sad, anxious, or empty. They may also experience feelings of hopelessness, pessimism, guilt, worthlessness, or helplessness. It's important to note that everyone's experience with depression is unique, and the impact on mood can vary widely. In some cases, certain interventions like creatine supplementation, which has been shown to elevate levels of activation and mood overall, might be beneficial. However, it's crucial to consult with a healthcare provider before starting any new treatment regimen.