Simple Steps to Boost Your Daily Energy with NAD | 1182 | Dave Asprey

CD 38 Impact

CD 38 plays a crucial role in NAD consumption, impacting inflammation and autoimmunity. Dr. Nichola Conlon explains that CD 38 has a high affinity for NAD, consuming 100 molecules per cycle, which can lead to increased inflammation and decreased NAD levels 1. This enzyme's activity can divert NAD from beneficial pathways, such as repair enzymes and sirtuins, exacerbating inflammation 2.

CD 38 will literally grab it before any other beneficial pathways that rely on NAD even get a look in.

--- Dr. Nichola Conlon

Inhibiting CD 38, even slightly, can significantly impact inflammation and NAD levels, highlighting the importance of addressing this enzyme in NAD boosting strategies 2.

   

Inflammation Reduction

Reducing chronic inflammation is vital for maintaining NAD levels and overall health. Dave Asprey emphasizes that NAD is not obtained from diet but produced within cells, and its production declines with age due to decreased activity of the enzyme NaMPT 3. Chronic inflammation exacerbates this decline by increasing the demand for NAD, driven by the enzyme CD 38 3.

Chronic low grade inflammation... is one of the most prolific NAD consumers.

--- Dr. Nichola Conlon

Addressing inflammation through lifestyle changes and supplementation can help restore NAD levels, offering benefits for energy and longevity, particularly in complex cases like perimenopausal women 4.