Addiction's Neuroadaptation Gremlins

Anna explains how addiction works in the brain, specifically how the release of dopamine creates a balance between pleasure and pain, and how the brain adapts to down regulate dopamine receptors and production, leading to an overwhelming urge to use more of the drug of choice to restore balance. She likens this adaptation to "neuroadaptation gremlins" that camp out on the pain side of the balance until the urge to restore neutrality becomes almost overwhelming.