Modern Stress
Anna explains that the constant stimulation and overabundance in modern life is a unique and unprecedented source of stress. Poor people living in rich nations are the most vulnerable to addiction due to access to highly potent, cheap forms of dopamine. Severe pain can trigger a compulsive, drug-seeking response due to the huge dopamine release it causes.In this clip
From this podcast

The Knowledge Project
The Science of Addiction | Dr. Anna Lembke | Knowledge Project 159
Related Questions
What does it mean that seeking too much pleasure can lead to a state where even high-dopamine activities lose their appeal in the context of the episode The Science of Addiction | Dr. Anna Lembke | Knowledge Project 159 and the clip Modern Stress
What is stress addiction?
Can stress trigger the desire to fuel an addiction, such as shopping?