Genetic Variants Explained
Manolis discusses the complexities of genetic variants, emphasizing that most fall outside protein-coding regions, making it challenging to identify which genes are affected. He highlights the FTO gene's association with obesity, revealing that the genetic variant linked to this gene actually influences two other genes located over a million nucleotides away, demonstrating the intricate nature of gene regulation.In this clip
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Lex Fridman Podcast
Manolis Kellis: Biology of Disease | Lex Fridman Podcast #133
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