Crohn's disease and ulcerative colitis are forms of inflammatory bowel disease characterized by chronic inflammation in the gastrointestinal tract. The exact drivers of these conditions remain largely unknown, but they can escalate from less severe gastrointestinal distress, such as IBS, into more serious forms of IBD. Insights reveal that the location of inflammation distinguishes between the diseases, with Crohn's often affecting the small intestine and ulcerative colitis targeting the large intestine.