Challenging Weight Loss Rules
Researchers challenge the traditional rule of "calories in, calories out" for weight loss, finding that it overpredicts weight loss by 100%. The longer and more restrictive the calorie intake, the harder weight loss becomes due to metabolic downshifts. Additionally, studies suggest that long-term calorie restriction may permanently damage metabolism.In this clip
From this podcast

Maintenance Phase
The Trouble With Calories
Related Questions
Is weight loss really just a matter of calories in and out as discussed in the episode How to Lose Fat with Science-Based Tools | Huberman Lab Podcast #21 and the clip Calories and Weight Loss?
Is the concept of "calories in, calories out" correct in the context of the Huberman Lab Podcast episode "Dr Layne Norton: The Science of Eating for Health, Fat Loss & Lean Muscle | Huberman Lab Podcast #97" and the clip "Energy Balance Explained," in relation to the episode #446: Metabolic Freedom: Ben Azadi’s Formula for Lasting Health and the clip Rethinking Weight Loss?
Is weight loss as simple as calories in versus calories out in the episode WEIGHT LOSS MYTHS: Everything You Have Been Told About Diet & Exercise is WRONG! | Dr. Tim Spector and the clip Rethinking Weight Loss?