What is Tmao?

TMAO (Trimethylamine N-oxide) is a compound that Andrew Huberman has mentioned in relation to L-carnitine supplementation. L-carnitine is involved in processing fats for mitochondrial function, which is important for various cellular activities, including fertility. However, oral ingestion of L-carnitine can lead to an increase in TMAO, which may cause stiffening of the arteries. To offset the increase in TMAO caused by L-carnitine, it is suggested to take garlic extract, which contains a compound called allicin that can reduce TMAO levels. The dosage recommended for the garlic extract is 600 milligrams per day, which can be taken at any time throughout the day 1.

In another discussion, it was pointed out that taking L-carnitine orally is not very bioavailable, and high oral doses could be required to achieve the desired amount of L-carnitine in the body. This might also lead to potential increases in TMAO, depending on the individual's gut microbiome. Here again, the same recommendation of taking 600 milligrams of garlic extract to reduce TMAO levels was mentioned. Additionally, allicin in garlic is reported to have positive effects on cardiovascular tone and blood flow 2.

Thus, while TMAO can be a byproduct of L-carnitine supplementation related to metabolic processes, mitigating strategies, such as the use of garlic extract, can help manage TMAO levels.