Nmn vs NR: Which is better?

When comparing NMN and NR (Nicotinamide Mononucleotide and Nicotinamide Riboside, respectively), both serve as precursors to NAD+, which is crucial for maintaining cellular health and potential longevity. Here's a breakdown of their benefits and differences based on the discussions by Dr. David Sinclair and Dr. Andrew Huberman:

NMN

• NMN is used by the body in one step to create NAD+, making it a direct precursor. Dr. David Sinclair notes that taking NMN can, on average, double NAD levels in the blood within about two weeks 1.
• Studies have shown that in mice, NMN can enhance physical endurance and blood flow, unlike NR which didn't show these effects in similar mouse studies 1.

NR

• NR, another precursor to NAD+, lacks the phosphate needed by the body, which could potentially pose concerns over high dosages as the body requires phosphates for crucial functions 1.
• Dr. Andrew Huberman has personally experimented with both NMN and NR, noting that each has distinct benefits. He emphasizes that the purpose of taking these supplements is not necessarily to extend lifespan but to enhance energy levels and vitality 2.

General Observations

• Both NMN and NR increase NAD+ levels, potentially improving cellular function and vitality.
• The choice between NMN and NR may depend on individual responses and the specific health goals one aims to achieve. Dr. Huberman has experienced increased energy levels using both, but prefers a combination of the two for his regimen 2.

In conclusion, while NMN might have some advantages in boosting physical performance and increasing NAD+ more directly, NR is still effective in increasing NAD+ levels. Personal experience and specific health objectives play significant roles in determining which supplement might be better suited for an individual.