What is P five P?

P five P, also known as Pyridoxal 5'-phosphate, is a metabolite of vitamin B6. It is known for its ability to suppress prolactin. This property is being explored in the context of reducing the so-called "crash" that occurs after ingestion of MDMA, which significantly increases prolactin levels. This increase in prolactin can lead to feelings of lethargy and lack of motivation. Although there are no human data yet from standardized clinical trials on the use of P five P to reduce prolactin after MDMA use, it is a subject of interest among clinicians treating conditions like PTSD with MDMA 1.