5 htp

Andrew Huberman has discussed 5-HTP extensively in his Huberman Lab podcast. Here are some key points:

1. Usage and Dosage:

   • 5-HTP is typically used to increase serotonin levels and is taken in doses of 300 to 500 milligrams. Users often take it before sleep, aiming for the last hour of wakefulness 1.

2. Effects on Sleep:

   • Huberman notes that while 5-HTP can lead to very deep sleep initially, it might also cause mid-night awakenings and disrupt overall sleep architecture due to the interaction of serotonin and melatonin systems. He doesn't include 5-HTP in his recommended sleep aids for this reason 2.

3. Individual Sensitivity:

   • People's responses to 5-HTP can vary significantly. Some find it very effective, while others, including Huberman himself, may experience disrupted sleep patterns 3.
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       1

       Serotonin Supplements

       01:53:28
       
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       2

       Glymphatic System Insights

       01:02:38
       
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       3

       Enhancing Gratitude Chemistry

       01:10:57
       
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       4

       Appetite and Serotonin

       00:46:37
       
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       5

       Hormone Modulation

       01:05:26

4. Serotonin and Appetite:

   • 5-HTP can blunt appetite by increasing serotonin levels, which is part of the body's mechanism to signal satiety and decrease the urge to eat. Long-term use is not generally recommended due to potential side effects, including increased cortisol levels 4.

5. Cognitive and Emotional Effects:

   • Higher serotonin levels can enhance feelings of contentment and gratitude. However, using supplements like 5-HTP for these purposes should be approached with caution due to the potential for disrupting natural sleep cycles 3.

6. Experimental Use:

   • Huberman has discussed the use of 5-HTP in experimental settings such as trying to mitigate the rebound effects following MDMA usage, although he stresses it's a powerful tool with potential downsides 5.

Be sure to consult with a healthcare provider before starting any new supplement regimen, as individual needs and reactions can vary.