Alzheimer's as brain diabetes?
Sources:
The concept of Alzheimer's disease as "brain diabetes," or sometimes referred to as "Type 3 diabetes," is based on the strong association between Alzheimer's and insulin resistance conditions like type 2 diabetes. In discussions between and , it's highlighted that Alzheimer's may fundamentally be a neuronal energy problem, where the brain experiences difficulty utilizing glucose due to insulin resistance. This inefficient energy usage is thought to contribute significantly to the disease's pathology.
The hypothesis is supported by evidence showing insulin resistance can increase the risk of Alzheimer's. For example, type 2 diabetes significantly elevates the risk of developing Alzheimer's. The potential mechanisms involve impaired insulin signaling and glucose metabolism in the brain, leading to cellular dysfunction and ultimately contributing to the symptoms and progression of Alzheimer's.
Additionally, the discussions touch upon dietary interventions like low glycemic index diets and the induction of ketosis, which have shown promising results in managing or reducing the risk of Alzheimer's by improving insulin sensitivity and metabolic health 1 2 3.
RELATED QUESTIONS
