How does curcumin treat headaches?

Curcumin, an active compound found in turmeric, has demonstrated significant anti-inflammatory properties, which are beneficial in treating headaches, particularly migraines. As explained by Andrew Huberman, studies have shown that Curcumin can be effective in reducing both the frequency and intensity of migraines. Notably, it does this by inhibiting pathways related to inflammation and potentially by reducing intracranial pressure through the inhibition of nitric oxide synthesis, which causes vasodilation.

For those considering Curcumin for migraine relief, dosages around 80 milligrams per day, often in conjunction with omega-3 fatty acids (about 2.5 grams per day), have been shown to offer benefits. However, high doses can affect other physiological processes such as the synthesis of dihydrotestosterone, possibly leading to undesirable effects like reduced libido. People on anticoagulants should also practice caution since Curcumin can affect blood coagulation processes 1 2.