Fadogia agrestis

Andrew Huberman addresses the use and considerations of Fadogia agrestis, a supplement that is often sought for its potential to enhance testosterone levels by increasing luteinizing hormone. He explains that the supplement can be beneficial, but there are significant safety considerations to keep in mind, especially regarding its dosage and potential toxicity to testicular cells if taken in high amounts.

Key Points on Fadogia Agrestis:

1. Toxicity Concerns: High dosages can be toxic to testicular cells, which makes it crucial to adhere strictly to recommended dosages. Cycling the supplement (e.g., eight weeks on, two weeks off) is advised to minimize potential risks 1.
2. Monitoring Through Blood Tests: Before and after implementing Fadogia agrestis or any hormone-affecting supplements, blood tests are recommended to ensure they're having the desired effect without adverse consequences 1.
3. Importance of Dosage: It is important not to exceed the recommended dosage as the compound can be toxic at high levels. The notion of more being better does not apply here, and starting with a lower dosage can be more prudent 1.
4. Potential Benefits: While Fadogia agrestis is known to boost hormone levels, especially testosterone, by stimulating luteinizing hormone, it's crucial to recognize the broader impact it may have, potentially influencing other hormones like estrogen as well 2.

Since Fadogia agrestis can influence multiple hormone levels, and due to its potential toxicity in high doses, Dr. Huberman emphasizes the importance of cautious use, guided dosage adherence, and regular monitoring through blood tests to guard against undesired effects.