Can Arginine increase growth hormone?

Yes, Arginine can increase growth hormone levels. Andrew Huberman explains that Arginine and Ornithine are known to substantially increase growth hormone levels, with increases ranging from 400% to 600% above baseline. Arginine's effects can be seen regardless of whether it's taken orally or intravenously, though the required amounts can cause gastrointestinal disturbances when taken in large doses. Typically, dosages from 3 grams to 10 grams are discussed, but he advises caution as more isn't always better and exceeding about 9 grams can blunt the growth hormone release 1.

Additionally, it is important to note that while Arginine before bedtime or exercise can increase growth hormone, if taken before exercise, it can negate the exercise's effects on growth hormone increase, stabilizing it to about 300% to 500% increases 2.