How to take metformin for longevity?

Andrew Huberman has discussed metformin on various occasions on the Huberman Lab podcast. Metformin is a prescription medication typically used to treat type 2 diabetes, but it's also being studied for its potential geroprotective, or longevity-promoting, effects. To understand how to potentially use metformin for longevity, it's important to examine key points brought up by Huberman and his guests:

1. Metformin and longevity benefits: Epidemiological data have suggested that individuals with type 2 diabetes taking metformin may live longer than expected, possibly longer than individuals without diabetes. These observations have led to interest in the potential longevity benefits of metformin beyond its blood glucose-lowering effects 1.

2. Intermittent use: Dr. David Sinclair mentioned during his conversation with Huberman that it might be beneficial to not take certain supplements, like metformin, every day. He personally takes metformin intermittently, in the morning along with resveratrol. On days when he exercises, he skips metformin since it can reduce stamina by inhibiting the body's ability to make energy 2.

3. Potential drawbacks: It's important to be aware of the potential side effects of metformin, such as gastrointestinal distress. Moreover, Dr. Peter Attia, who previously took metformin, found that it increased his lactate levels at rest, indicating a potential issue for those who are very physically active. He ultimately decided to stop taking it, particularly due to the effects on his exercise performance and lactate production 3.

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     1

     Metformin's Impact

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     2

     Metformin and Longevity

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     3

     Metformin and Lactate

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     4

     Metformin's Geroprotective Potential

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4. Target demographic: Attia has indicated that while metformin can be valuable for those who are insulin resistant, it might not be a great choice for individuals who are insulin sensitive and who exercise regularly 4.

5. TAME study anticipation: Results of the TAME (Targeting Aging with Metformin) study are awaited to provide more definitive evidence on the geroprotective benefit of metformin in non-diabetics. This upcoming data may reshape the current understanding of metformin as a longevity drug 4.

Huberman and his guests caution that the decision to use metformin for longevity should not be taken lightly and should be discussed with a healthcare provider, especially considering the current lack of conclusive evidence, potential side effects, and individual variability related to insulin sensitivity and activity levels. Always consult with a healthcare professional before starting any new medication or supplement, particularly for off-label uses such as longevity.