What is the serotonin hypothesis?
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The serotonin hypothesis suggests that a deficit in serotonin levels or its functioning in the brain is directly linked to depression. This formed the rationale behind treatments such as SSRIs (Selective Serotonin Reuptake Inhibitors) which are designed to increase serotonin availability in the brain. However, recent discussions, as highlighted by , have challenged this hypothesis, proposing that these treatments might function through mechanisms other than directly altering serotonin levels 1 2 3.
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