Causes of diabetes

Type 2 diabetes is primarily associated with insulin resistance, which is influenced by:

1. Energy Imbalance and Accumulation of Fat: Excess accumulation of fat, particularly in the pancreas and liver, can lead to inflammation and impaired insulin production by the pancreas, exacerbating insulin resistance 1.

2. Physical Inactivity: Lack of sufficient physical activity is a significant cause of insulin resistance. Clinical studies have shown that even lean individuals who are inactive can exhibit signs of insulin resistance 1.

3. Sleep Deprivation: Insufficient sleep can drastically reduce glucose disposal, effectively inducing insulin resistance within a week 1.

These factors contribute to a complex metabolic dysfunction, where the body becomes less responsive to insulin, necessitating higher levels to manage blood glucose levels effectively.