Causes of diabetes


Type 2 diabetes is primarily associated with insulin resistance, which is influenced by:

  1. Energy Imbalance and Accumulation of Fat: Excess accumulation of fat, particularly in the pancreas and liver, can lead to inflammation and impaired insulin production by the pancreas, exacerbating insulin resistance 1.

  2. Physical Inactivity: Lack of sufficient physical activity is a significant cause of insulin resistance. Clinical studies have shown that even lean individuals who are inactive can exhibit signs of insulin resistance 1.

  3. Sleep Deprivation: Insufficient sleep can drastically reduce glucose disposal, effectively inducing insulin resistance within a week 1.

These factors contribute to a complex metabolic dysfunction, where the body becomes less responsive to insulin, necessitating higher levels to manage blood glucose levels effectively.

Understanding Type 2 Diabetes

Peter Attia explains the vicious cascade of insulin resistance in type 2 diabetes, highlighting the role of fat accumulation in the pancreas and liver. He also discusses the importance of physical activity and the impact of sleep deprivation on insulin resistance.

Huberman Lab

Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects