How does exercise affect osteocalcin?

Exercise, particularly load-bearing exercise like weightlifting, running, or other activities involving jumping and landing, plays a significant role in the release of osteocalcin. According to Andrew Huberman, load-bearing exercise stimulates the release of osteocalcin from bones, which then travels through the bloodstream to the brain. This process enhances the function of the hippocampus, promoting memory and learning 1 2.

Osteocalcin acts as a hormone, having endocrine effects on various parts of the body, including the brain. It supports neuron health and encourages the formation and maintenance of neural connections within the hippocampus, which is crucial for laying down new memories 2. Additionally, load-bearing exercises improve cognitive function by sending hormonal signals from the body to the brain, indicating movement and enhancing brain circuitry 3.

Furthermore, cardiovascular exercise also contributes to osteocalcin release, albeit primarily through increased blood flow rather than direct skeletal stimulation. Overall, exercise, by promoting osteocalcin release, not only supports bone health but also significantly benefits brain function, particularly memory and learning 4.