Are sugar substitutes safe?

Regarding the safety of sugar substitutes, Andrew Huberman and Peter Attia have discussed this topic extensively. They emphasize that while sugar substitutes like aspartame do not cause cancer, they can influence brain and gut chemistry, which may affect metabolism. This led them to advise caution with artificial sweeteners and recommend limiting consumption. They found xylitol and alulose to be reasonable and safer options compared to other artificial sweeteners. Dr. Huberman occasionally consumes drinks with stevia and avoids sucralose due to personal taste preferences 1 2.