Fish oil protocol

Andrew Huberman has discussed a specific protocol involving omega-3 fatty acids, particularly focusing on the ratio of omega-3 to omega-6 fatty acids and its impact on mood and depression. He has personally found significant benefits from adjusting this ratio, noting its profound effects backed by scientific studies. Huberman highlights a study where a daily intake of 1000 milligrams of EPA (a type of omega-3 fatty acid found in fish oil) was found to be equally effective as 20 milligrams of fluoxetine (Prozac) in reducing depressive symptoms in clinically depressed individuals. Furthermore, combining EPA with fluoxetine showed a synergistic effect in improving depressive symptoms.

He also mentions taking a high dosage of fish oil (9.6 grams per day) in a study showed substantial benefits for reducing symptoms of bipolar depression compared to a control group. It's important to note that while omega-3 supplementation can be beneficial, it should not be viewed as a standalone treatment, particularly for serious conditions like bipolar disorder.

For general well-being, Huberman himself takes 1000 milligrams per day of EPA in fish oil, noting an improvement in mood and affect. It's advised that individuals with specific health conditions like blood clotting issues or those on certain medications should consult a doctor before starting a fish oil regimen due to potential side effects, such as fishy breath or increased bleeding risk.

Overall, Huberman recommends omega-3 supplementation as a beneficial addition to a well-rounded treatment approach that may include prescription medication, talk therapy, and lifestyle changes.1 2