NRF Two

Nuclear factor erythroid 2–related factor 2, commonly abbreviated as NRF2, is a transcription factor that plays a critical role in the antioxidant response of cells. It binds to specific sequences in genes, regulating the activation or repression of those genes. NRF2 is especially significant in the detoxification process. For instance, it activates various genes associated with detoxifying pathways, which can help in reducing the harmful effects of airborne pollutants like benzene from cigarette smoke and air pollution. This process can be significantly enhanced by compounds found in foods like broccoli sprouts, which have been shown to increase the activation of NRF2, leading to greater excretion of harmful substances like benzene and acrylene 1.