What technologies are driving radical longevity?

Several technologies are key drivers of radical longevity, each addressing different aspects of aging and health:

1. Gene Editing and Manipulation: This involves altering specific genes to extend lifespan. Research has shown that modifying genes can significantly increase the longevity of organisms from worms to mice, though translating this to humans remains complex 1.

2. Cellular Senescence and Senolytics: These focus on removing senescent, or "zombie," cells that contribute to aging and inflammation. Approaches that clear these cells can potentially rejuvenate tissues and extend healthspan 2.

3. AI and Machine Learning: Advanced AI technologies help discover new drugs and understand cellular mechanisms affecting longevity. Companies are using AI to identify molecules that enhance cell lifespan, heralding a potential revolution in health and longevity science 3.

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     1

     Unlocking Longevity

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     2

     Longevity Breakthroughs

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     3

     Longevity Revolution

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     4

     Lifespan Revolution

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4. NAD and Sirtuins: These molecules and proteins play a key role in cellular health and longevity. Boosting NAD levels and activating sirtuins can protect cells under stress, potentially extending lifespan and healthspan 2.

5. Calorie Restriction Mimetics: Compounds that mimic the effects of calorie restriction, like intermittent fasting, are being explored for their ability to trigger protective cellular pathways without the need to significantly reduce food intake 4.

These technologies are at different stages of development and acceptance, but together they form a promising portfolio aimed at dramatically increasing human lifespan and improving quality of life.