HPA axis


The HPA axis, also known as the hypothalamic–pituitary–adrenal axis, plays a critical role in the body's response to stress. Dr. Mithu Storoni explains that the HPA axis is a hormonal pathway activated during stress reactions. This system is part of our body's survival mechanism, which has evolved to help us adapt to threats. The HPA axis involves a cascade of hormones starting from the hypothalamus, which then triggers the pituitary and adrenal glands, leading to the release of cortisol. Cortisol, often in conjunction with adrenaline, helps mobilize energy sources in response to stress, enhancing the body's ability to handle threats but also potentially causing inflammation. This adaptive response is crucial for immediate survival but can have detrimental effects if activated too frequently or intensely 1 2.

Rethinking Stress

Dr. Mithu Storoni challenges our understanding of stress, highlighting the blurred definition and the physiological reactions that occur in the body. She explains how stress is a survival mechanism, rooted in our evolutionary history of escaping predators. By delving into the seven pathways triggered during a stress response, she provides actionable insights for managing stress.

The Neuro Experience with Louisa Nicola

Stress Proof Your Brain - Dr Mithu Storoni MD, PhD