Should severity of cases be assessed?
Sources:
Yes, assessing the severity of cases is important. In clinical trials for vaccines, researchers examined various endpoints ranging from asymptomatic infections to severe cases requiring ICU admission and even death. However, there were limitations in these trials due to the relatively low number of severe cases. For example, trials for the Moderna and Pfizer vaccines reported that severe cases requiring hospitalization or leading to death were infrequent, making it challenging to assess vaccine efficacy against these endpoints without much larger or longer trials. Therefore, while assessing the severity of cases is crucial, current trial designs may not always capture enough severe events to draw robust conclusions about these outcomes 1 .
Examining Vaccine Efficacy
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