Spermidine

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Spermidine and Autophagy

Dr. Matt Kaeberlein discusses the benefits of spermidine in a conversation with Tim Ferriss on . Here are the key points:

  • Correlation with Health Outcomes: Studies show a relationship between dietary spermidine intake and reduced mortality, along with improved health markers.
  • Lifespan Extension: Research indicates that spermidine can extend lifespan in various organisms. Particularly, there is evidence of improved healthspan (quality of health) in mice.
  • Mechanism: Spermidine boosts autophagy, a process regulated by mTOR that helps clear out damaged cellular components. This "recycling" process renews cellular function by breaking down old parts and using them to construct new ones.
  • Comparison to Rapamycin: Like spermidine, Rapamycin also promotes autophagy.

Dr. Kaeberlein mentions that companies are developing pharmacological autophagy boosters, highlighting spermidine's potential in longevity research and healthspan improvement 1.

For those interested in diving deeper into this topic, the episode is part of "The Life-Extension Episode With Dr. Matt Kaeberlein" hosted by Tim Ferriss.

Boosting Autophagy

Dr. Matt explains how spermidine and Eurolithan A can enhance autophagy, the cellular recycling process, leading to potential lifespan extension and improved healthspan. He also discusses the benefits of Eurolithan A in restoring metabolic function through mitophagy.
Tim Ferriss Show
The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show
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