How to decrease Tmao conversion?

To decrease the conversion of trimethylamine N-oxide (TMAO), several strategies can be employed:

1. Garlic Extract: Taking garlic extract can counteract the increase in TMAO levels. Specifically, consuming 600 milligrams of garlic extract daily has been recommended by Andrew Huberman when consuming substances like L-carnitine, which can increase TMAO levels 1.

2. Allicin in Garlic: Allicin, a compound found in garlic, helps decrease TMAO conversion. Therefore, integrating garlic in your diet, or specifically allicin-rich garlic supplements, can mitigate TMAO production 2.

3. Berberine: This compound, though it can have side effects like headaches and hypoglycemia, also contributes to reducing TMAO conversion. Berberine acts likely through altering the gut microbiome 2.

4. Optimizing Gut Microbiome: A healthy gut microbiome can naturally decrease TMAO conversion. This might involve dietary changes or probiotics 2.

5. Reducing Intake of TMAO Precursors: Besides supplements, being cautious about dietary precursors to TMAO, such as excessive red meat (which is high in L-carnitine) and eggs (high in choline), can be beneficial.

Implementing these strategies could help minimize TMAO conversion, which is linked with various health risks like cardiovascular disease. Always consult healthcare professionals before making significant changes to your diet or supplement regimen.