Is fructose in fruit fattening?

According to Andrew Huberman, the fructose found in fruit is generally not fattening due to its relatively low concentrations when compared to forms of fructose like high fructose corn syrup. He highlights that fruits contain not only fructose but also various other types of sugars and nutrients. While high fructose corn syrup contains approximately 50% fructose, fruit generally contains anywhere from 1% to 10% fructose, varying quite a bit from one type of fruit to another. Dr. Huberman points out that unless one is consuming large quantities of fruit or consuming it alongside a highly processed diet, it would not be accurate to consider fruit as fattening due to fructose content 1.

However, it's worth noting that while Huberman remarks that ingesting fructose can lead to an increase in hunger due to its ability to reduce the activity of hormones that suppress hunger, eating an apple or a few pieces of fruit should not lead to excessive eating behavior. He states that fructose shifts our hormone system in a way that can make us hungrier regardless of caloric intake, but the effects are not significant with normal fruit consumption 2. It's important to be aware that excessive intake of any sugars, including fructose, should be avoided and a balanced diet is always recommended for maintaining a healthy weight.