Neurogenetic Disorder

Neurogenetic disorders involve the intricate interplay between genetic factors and neurological diseases, leading to various impairments and conditions. Here are some insights from experts based on recent podcast discussions:

1. Genetic Predispositions in Parkinson's: Dr. Kellyann Niotis explains that only about 10% of Parkinson's disease cases are linked to a clear genetic pathology, with specific genes like GBA and LRRK2 being significant. However, our understanding of Parkinson's genetic architecture lags significantly behind that of Alzheimer's disease, where about two-thirds of cases are associated with at least one copy of the APOE4 gene 1.

2. Neurodevelopmental and Degenerative Disorders: Understanding the prefrontal cortex is crucial because damage here can lead to both neurological and psychiatric disorders. For example, traumatic brain injuries or deficits in the prefrontal cortex can result in impaired social regulation and disorders like schizophrenia or OCD. Research in this area aims to develop effective therapies and remediation strategies for various conditions 2.

These insights reflect the current research and genetic considerations in understanding and potentially treating neurogenetic disorders. For a more in-depth discussion, you might explore the episodes featuring these discussions:

• Brain-Computer Interfaces and Neural Decoding on the Super Data Science: ML & AI Podcast with Jon Krohn
• Neurodegenerative disease: pathology, screening, and prevention on the The Peter Attia Drive Podcast

These episodes provide detailed examinations from experts like Dr. Kellyann Niotis and neuroscientist Bob Knight on the subject.