Ace Two Receptor


The ACE2 receptor plays a significant role in the body's response to the SARS-CoV-2 virus, the cause of COVID-19. This receptor is one of the primary ways the SARS-CoV-2 virus enters human cells. It binds to ACE2 on the cell surface, which facilitates the virus's entry into the cell. This action leads to a decrease in the number of functioning ACE2 receptors, which worsens the severity of disease caused by the virus.

Rhonda Patrick discusses several aspects of ACE2 in relation to COVID-19:

  • Role in respiratory system: ACE2 is crucial for protecting against acute lung injury and acute respiratory distress syndrome, significant complications associated with severe COVID-19 cases. The loss of ACE2 function can lead to increased lung injury and inflammation.
  • Impact of ACE inhibitors and ARBs: There's a consideration that ACE inhibitors and ARBs (angiotensin receptor blockers), commonly used in treating hypertension, might influence ACE2 levels. These medications are thought potentially to decrease the severity of COVID-19 by increasing ACE2 levels, although more data is needed to confirm this effect fully.
  • Vitamin D: Vitamin D plays a role in regulating ACE2 levels. In conditions like acute lung injury where ACE2 levels decrease, vitamin D can help rebalance ACE2 levels, potentially offering protective effects against severe virus-induced lung injury 1 2.

This information underscores the interconnected nature of ACE2 in various health conditions and its importance in the context of COVID-19.

Vitamin D and Ace2

Rhonda explains how vitamin D plays a crucial role in the innate immune response and how Ace2 is important for protecting against acute lung injury and acute respiratory distress syndrome. She also discusses the role of Ace2 in the renin angiotensin system and how an imbalance can lead to serious health consequences.

FoundMyFitness Just Me

COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.