Acarbos

Acarbose is a medication discussed by Andrew Huberman and Dr. Peter Attia on the podcast The Peter Attia Drive. Acarbose functions primarily in the gut to prevent the absorption of glucose, acting as a glucose disposal agent. Interestingly, it has been shown to provide a survival benefit without inducing weight loss. This benefit is attributed to its effects on lowering blood glucose and insulin levels rather than calorie restriction.

In their conversation, they mention that Acarbose was found to have a survival benefit in the ITP (Interventions Testing Program), attracting attention because it could act as a caloric restriction mimetic by preventing the absorption of about 15-20% of carbohydrates. This could lead to similar benefits as caloric restriction without actually reducing caloric intake. The hypothesis was that by reducing carbohydrate absorption, Acarbose could indirectly extend lifespan by maintaining lower glucose and insulin levels, which is beneficial for overall metabolic health and longevity 1.

For more insights and medical opinions about Acarbose, you can refer to the episode titled "270 ‒ Journal club with Andrew Huberman: metformin, power of belief, & how to read scientific papers" on The Peter Attia Drive The Peter Attia Drive.