What are the safety concerns of combining them?

Combining Fadogia agrestis with Tribulus can pose certain safety concerns, especially given the potential risks associated with each supplement individually. Here are the main points to consider:

1. Fadogia Agrestis:

   • Fadogia agrestis has shown potential for increasing testosterone through luteinizing hormone release. However, it does have toxicity concerns, particularly regarding testicular cells observed in animal studies. Even though toxicity hasn't been established at typical human dosages, experts like Andrew Huberman advise following recommended dosages and cycling the supplement to mitigate any potential long-term effects 1.

2. Tribulus:

   • Tribulus is often promoted for enhancing testosterone and treating erectile dysfunction, but its effectiveness and safety are debated. Dr. Rena Malik highlights studies suggesting conflicting results, with some data showing improvements in erectile function. However, there are severe side effects such as renal and liver failure, making its use for these purposes questionable 2.

3. General Safety Considerations:

   • Since both supplements affect hormone levels and have associated safety concerns, combining them might elevate the risks of adverse effects. It's critical to adhere to recommended doses, cycle the supplements, and monitor their impact through blood tests to ensure hormone levels and overall health are not negatively affected 3.
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       Hormone Supplement Caution

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       Supplements for Erectile Dysfunction

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       3

       Supplement Safety Concerns

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Given the lack of comprehensive studies on the combined use of these supplements, caution and consultation with a healthcare provider are advised before considering their concurrent use.