How does Dinitrophenol work?

Dinitrophenol (DNP) is a highly dangerous compound known for its thermogenic properties, which can lead to significant weight loss by increasing the body's temperature and metabolic rate. It was discovered inadvertently during World War II when workers in ammunition factories who were exposed to it started losing weight rapidly. The mechanism by which DNP works involves increasing the metabolism of cells by uncoupling oxidative phosphorylation in the mitochondria. This process leads to the inefficient use of energy, causing heat production rather than ATP (energy) synthesis. As a result, the body burns more fat to produce the same amount of ATP, leading to weight loss.

However, DNP is extremely hazardous because it can cause hyperthermia (excessive body heat), which can be fatal. There have been numerous cases of death due to its usage as a weight-loss drug, predominantly within niche communities like bodybuilding. Andrew Huberman strongly discourages anyone from using DNP due to its high risk of fatal hyperthermia 1 2.