Is sucralose harmful?

Sucralose, a commonly used artificial sweetener, has been shown to potentially impair neural and metabolic sensitivity to sugar when consumed with carbohydrates. This finding is based on a study published in "Cell Metabolism," which indicates that sucralose consumption should be managed carefully, particularly in relation to meals that increase blood glucose levels. Additionally, the study suggests that such consumption could alter the brain's dopamine system, which is responsible for pleasure and reward responses 1.

Furthermore, there is some evidence suggesting that sucralose might alter the gut microbiome. This effect was noted in a longer-term study (ten weeks), indicating changes in the microbiome that could potentially be linked to improved insulin sensitivity and lower adiposity, although the overall health implications of such changes are not entirely clear yet 2.

In conclusion, while sucralose is not entirely harmful, it should be used cautiously, especially in combination with carbohydrate-rich foods. Its long-term effects, particularly on the gut microbiome and blood sugar regulation, require more research to fully understand their implications on health.